Los Casagrandes is being developed to have Ronnie Anne and Bobby Santiago adjust to their new life in the city, where they now live with their big, loving and chaotic multi-generational family, the Casagrandes. In the series, Ronnie Anne will make new friends, build stronger bonds with her relatives and explore the endless possibilities the city life has to offer. Bobby will help Grandpa Hector run the family's corner store, and becomes familiar with the neighborhood’s quirky characters.
Ronnie Anne Santiago (voiced by Breanna Yde) - At age 11, Ronnie Anne Santiago is the cousin, niece, and granddaughter of the Casagrandes. Ronnie Anne is a tomboy who doesn't mess around with "girly stuff".
Bobby Santiago (voiced by Carlos PenaVega) - At age 17, Bobby is a jack of all trades, having had to juggle multiple jobs at the same time. Bobby is shown to be calm and compassionate, but sometimes a little too absentminded.
Carlos Casagrande (voiced by Carlos Alazraqui) - Carlos is the father of the Casagrande siblings, the son of Rosa and Hector, the husband of Frida Puga, and the brother of Maria Santiago. He loves reading books and sharing the knowledge he gathered from them.
Frida Puga Casagrande (voiced by Roxana Ortega) - Frida Puga is the mother of the Casagrande siblings, the wife of Carlos, the daughter in-law of Rosa and the sister in-law of Maria Santiago. She is an avid photographer.
Carlota Casagrande (voiced by Alexa PenaVega) - At age 17, Carlota is the oldest child and only daughter of the Frida Puga and Carlos and a fashion loving girl. She can be seen shouting at Carlitos for using her cosmetics.
Carlos Jr. Casagrande (voiced by Jared Kozak) - At age 13, CJ is the oldest son of the Casagrandes. CJ also has the genetic disorder called Down syndrome. He is a lover of playing pirate and an incredibly sweet boy.